ClickChemistryTools點(diǎn)擊化學(xué)銅穩(wěn)定配體BTTAA選購(gòu)指南

BTTAA是一種 Cu(I) 穩(wěn)定配體。能夠長(zhǎng)時(shí)間保持Cu(I)的催化能力，從而更好的進(jìn)行ADC合成。BTTAA 的性能遠(yuǎn)遠(yuǎn)優(yōu)于 THPTA 或 TBTA。

結(jié)構(gòu)圖：

中文簡(jiǎn)介：

BTTAA 是最新一代的 CuAAC 水溶性加速配體，與上一代配體（例如 THPTA 或 TBTA）相比，它提供了更大的速率增強(qiáng)。更重要的是，它最大限度地減少了對(duì)所探測(cè)細(xì)胞或生物體生理狀態(tài)的擾動(dòng)，并通過進(jìn)一步降低催化劑制劑中的銅負(fù)載，實(shí)現(xiàn)與抑制細(xì)胞細(xì)胞毒性的有效生物偶聯(lián)。

英文簡(jiǎn)介：

BTTAA is a newest generation, water-soluble accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering copper loading in the catalyst formulation.

ClickChemistryTools點(diǎn)擊化學(xué)銅穩(wěn)定配體BTTAA選購(gòu)指南--文獻(xiàn)參考：

1. Graham, A. J., et al. (2022). Extracellular Electron Transfer Enables Cellular Control of Cu(I)-Catalyzed Alkyne-Azide Cycloaddition. ACS Cent Sci., 8 (2), 246-257.

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6. Jun Kit Ow, M., et al. (2020). Super-Resolution Fluorescence Microscopy Reveals Nanoscale Catalytic Heterogeneity on Single Copper Nanowires. ACS Appl. Nano Mater.,, 3, 4, 3163–7.

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8. Uttamapinant, C., et al. (2012). Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling. Angew. Chem. Int. Ed,., 51, 5852-56.

9. Besanceney-Webler, C., et al. (2011). Increasing the efficacy of bioorthogonal click reactions for bioconjugation: a comparative study. Angew. Chem. Int. Ed,. 50 (35): 8051–6.